- Assia BENSALEM*, MD, PhD; Abdelaziz AMMARI, PhD & Sihem BENSALEM, MD
- Medical Oncology Department, Hospital Establishment DIDOUCHE Mourad, Faculty of Medicine, University Constantine 3, ALGERIA
- DOI: 10.5281/zenodo.20389853
Background:
Pregnancy-associated breast cancer (PABC) presents unique diagnostic and
therapeutic challenges due to the need to balance maternal and fetal health.
This retrospective study aims to analyze the clinical, pathological, and
prognostic features of PABC in a cohort of patients.
Methods: Eight
cases of PABC diagnosed between 2021 and 2025 at the Medical Oncology
Department of EH Didouche Mourad Hospital were retrospectively reviewed. Data
on epidemiology, clinical presentation, histopathology, treatment, and outcomes
were collected.
Results: The mean
age at diagnosis was 32 years. Tumors were predominantly invasive ductal
carcinoma (75%), with 50% being grade III and 50% showing lymph node
involvement. Hormone receptor-positive, HER2-positive, and triple-negative
subtypes each accounted for 37.5% of cases. Treatment included surgery (50%),
chemotherapy (37.5%), and radiotherapy (50%). The mortality rate was 37.5%,
with a relapse rate of 25%.
Conclusion: PABC is
associated with aggressive tumor biology and poor prognosis, particularly in
advanced stages and triple-negative subtypes. Multidisciplinary management is
essential to optimize outcomes.
